You are here

Scientific Leadership Team

Joshua Apgar, PhD

Co-Founder and CSO

Before co-founding Applied BioMath Josh was a Principal Scientist in the Systems Biology Group of the Department of Immunology and Inflammation at Boehringer Ingelheim Pharmaceuticals. His work leveraged physics-based models to: translate in vitro and in vivo data, assess target feasibility, understand drug mechanism of action, and predict human doses. The ultimate goal of this work was to reduce late stage attrition in drug development through a deep and quantitative interrogation of drug pharmacology and disease pathophysiology.

Read More
John M. Burke, PhD

John M. Burke, PhD

Co-Founder, President, and CEO

Dr. Burke’s BS and MS are in Applied Mathematics from the University of Massachusetts, Lowell, in 1993 and 1995, respectively. His PhD degree is in Applied Mathematics from Arizona State University in 2003. His research interests include singularly and randomly perturbed differential equations, bifurcation theory, and applying dynamical systems theory to study and understand how cells and tissues make decisions in humans, and human disease.

Read More
Lore Gruenbaum, PhD

Lore Gruenbaum, PhD

Executive Director of Biology and Pharmacology

Lore Gruenbaum is a biochemist and molecular biologist with 15 years of experience in drug discovery and clinical development of small and large molecules as well as diagnostics and personalized health care approaches. Lore was most recently employed as the Director of Biomarker Strategy, Infectious Diseases at the Roche Translational Clinical Research Center in New York City where she was responsible for drug target and biomarker identification, preclinical and clinical biomarker studies and experimental medicine studies. Lore obtained her doctorate in Biochemistry with ‘Summa cum Laude’ from the Free University of Berlin and completed her postdoctoral training in Neuroscience at Yale University in the laboratories of Prof. Tom Carew and Prof. Marina Picciotto. 

Read More
Jim Hilbert, PhD

Jim Hilbert, PhD

Senior Fellow

Jim has extensive background in the Clinical Pharmacology development of both small molecules and monoclonal antibodies.  As a clinical pharmacokineticist, he has been directly involved with preparation of PEI briefing documents and US FDA and EMA submissions, including INDs and NDAs, and representing Boehringer-Ingelheim (BI) at Paul Ehrlich Institute (PEI) briefings and US FDA pre-IND meetings.  Jim has contributed to BI Projects in the immunology, virology, respiratory and oncology therapeutic areas, and he has organized and trained the BI PK Data Evaluation and Reporting group for BI in Ridgefield.

Read More
Conrad Housand, MSc

Conrad Housand, MSc

Principal Scientist

Conrad brings over 20 years of experience in software design and development related to numerical simulation tools and platforms, including both commercial and government-funded tools for applications including computational biology, pharmacokinetics and human health risk assessment. 

Read More
Fei Hua, PhD

Fei Hua, PhD

Director of Modeling and Simulation

Dr. Fei Hua is trained as a biologist and systems modeler with 11 years of drug discovery and development experience working in a variety of disease areas and with both large and small molecules. Before joining ABM, Dr. Hua worked at Pfizer Inc. in non-clinical groups to build systems biology models to help target differentiation, lead selection and biomarker identification.

Read More
Dooyoung Lee, PhD

Dooyoung Lee, PhD

Senior Scientist

Prior to joining Applied BioMath, Dooyoung was a Scientist at FORUM Pharmaceuticals, Inc (Waltham, MA) where he worked on developing and implementing quantitative models in preclinical/translational development of medicines for serious brain diseases including PK/PD, Physiologically-Based PK and Systems Pharmacology. He has expertise in systems pharmacology modeling, mechanistic modeling and intracellular pathway modeling in biological systems. 

Read More
Lin Lin, PhD

Lin Lin, PhD

Senior Scientist

Lin received her BS in Biomedical Engineering from Tsinghua University, China in 2009 and completed her PhD at University of Minnesota, Twin Cities in 2016.  Her doctoral work focuses on modeling biological signal pathways and networks for use in understanding patterning and growth control in cell and tissue development. Her work also involves numerical PDE and ODE analysis, parameter estimation and sensitivity analysis. In addition to systems biology, she has hands-on experience in medical imaging and physiological signal processing. 

Read More
Kumpal Madrasi, PhD

Kumpal Madrasi, PhD

Senior Scientist

Kumpal received his Ph.D. in biomedical engineering from Florida International University where he started working on mathematical models exploring nitric oxide transport in the vasculature as nitrite and nitrosothiols. He did his fellowship at Mercer University working on modeling adherence of drugs for HIV and modeling uptake and activation of these drugs into peripheral blood mononuclear cells. He followed this up with another fellowship at University of Florida and FDA working on modeling disease progression and treatment for postmenopausal osteoporosis. 

 

Read More

Andrew Matteson, PhD

Principal Scientist

Before joining Applied BioMath, Andrew was a Senior Software Engineer at The MathWorks where he worked on the SimBiology, Bioinformatics, and Machine Learning toolboxes. He has expertise in parameter estimation for biological systems, quantitative systems pharmacology, and machine learning.

Andrew received his doctorate in computational biology from NYU's Courant Institute. Throughout his graduate work, Andrew worked closely with Merrimack Pharmaceuticals, providing computational and software support for several programs. Outside of work he enjoys dance, circus arts, and atrociously bad movies.

 
Bjorn Millard, PhD

Bjorn Millard, PhD

Principal Scientist

Bjorn is a computational & systems biologist with a diverse set of experiences in pharma R&D and manufacturing. He previously worked at Silver Creek Pharmaceuticals in San Francisco, CA, using computational models to help engineer regenerative protein therapeutics. Prior to that, he was a modeling and simulation engineer with the RES Group in Needham, MA where he built and optimized organic synthesis reactor models for large pharma API manufacturing. He also spent 2 years at Merrimack Pharmaceuticals in Cambridge MA where he developed image analysis algorithms applied to a new quantitative IHC diagnostic assay used in multiple Phase 2 clinical trials. Bjorn received his Ph.D. from Harvard University in Systems Biology, with a primary focus on computational methods development applied to cancer systems pharmacology.

 

Read More
Anna Katharina Wilkins, PhD

Anna Katharina Wilkins, PhD

Senior Scientist

Katharina holds graduate degrees in Biotechnology and in Chemical Engineering, having graduated from the Ecole Superieure de Biotechnologie de Strasbourg and from the Department of Chemical Engineering at MIT. Her doctoral work in advancing mathematical methods for the sensitivity analysis of oscillating systems, with particular application to biological systems such as the circadian clock, led to a more detailed functional understanding of the design of molecular networks. Other areas of interest included new approaches to parameter fitting, especially relevant to feature-rich but data-poor biological systems. Prior to joining Applied Biomath, Katharina worked as a Visiting Research Fellow at New England Biolabs, Inc., and as a Computational Software Engineer on the algorithms team at Rhythmia Medical (now Boston Scientific). 

Read More
Katie Williams, PhD

Katie Williams, PhD

Senior Scientist

Katie earned her PhD in Applied Mathematics from the University of Arizona this Spring with a dissertation titled "Anti-cancer treatment and the cell cycle: Cellular-level mathematical models."  She also interned with Takeda Pharmaceuticals from 2014 - 2016 in both the Clinical Pharmacology and Modeling & Simulation departments where she developed mathematical models to support teams in many stages of drug development.

Read More
Carissa Young, PhD

Carissa Young, PhD

 Senior Scientist

Carissa earned a BS in Chemical Engineering from Georgia Tech in 2002 and a PhD from the University of Delaware in 2011, where she was awarded an NSF-IGERT fellowship in Biotechnology and NIH-sponsored institutional grants.

 

As a systems biologist and protein engineer, Carissa’s prior research has focused on disease physiology, intracellular signaling, biomarker discovery, cell stress pathways, computational modeling, advanced microscopy, organ-on-chip platforms, protein and cellular engineering. With > 7 years experience in multiple facets of R&D, process development, and manufacturing, Carissa has been employed by Johnson & Johnson as a process engineer in biotechnology, a Research Scientist at the Delaware Biotechnology Institute BioImaging Center, and as a MIT postdoc in Biological Engineering focused on metastatic cancer progression, liver and lung inflammation.

Read More
Ora Zyto, PhD

Ora Zyto, PhD

Senior Software Engineer

Prior to joining Applied BioMath, Ora worked as a Research Scientist at NormaTec, where she designed clinical research protocols for a non-invasive medical device. More recently, she worked at MathWorks, first as an Advanced Support Engineer, then becoming a Senior Quality Engineer, where she supported SimBiology and the Bioinformatics toolbox.   
 
Ora earned her PhD in Biological Engineering from MIT, after having graduated from the Ecole Polytechnique (France). Her doctoral work focused on developing new computational methods to better understand how mechanical forces affect protein structure and function. 
 
 
 

Read More