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NBE Feasibility Assessment

Triage Targets for Multi-Targeting Biologic
Situation: 

There was a long list of potential multi-targeting pairs for a chronic inflammatory disease. The marketing requirement for this drug was monthly subcutaneous administration. It was anticipated that dosing would be a challenge. It was unclear how to pick compatible pairs of targets.

Solution: 
  1. Developed a systems pharmacology model for each target
  2. Established affinity and dose requirements for each target
  3. Benchmarked predictions using data from known monotherapies
  4. Eliminated targets with low developability
  5. Set up screening funnel for top candidates based on predicted affinity requirements
Result: 
  • Eliminated dead ends early before significant time and resource investment
  • Freed up researchers to pursue other promising business objectives
  • Accelerated timelines for promising candidates