Gene Therapy Model Pack
Applied BioMath Assess™ Gene Therapy Model Pack includes 8 models covering LNP-encapsulated mRNA and siRNA therapies.
- LNP-encapsulated mRNA expressing an intracellular protein in vitro
- Two-compartment model of mRNA uptake, protein expression, and protein-mediated enzymatic reaction in vitro
- LNP-encapsulated mRNA expressing an intracellular protein in vivo
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
- LNP-encapsulated mRNA expressing an extracellular protein in vitro
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vitro
- LNP-encapsulated mRNA expressing an extracellular protein in vivo
- Two-compartment model of mRNA delivery, protein expression, and protein-mediated enzymatic reaction in vivo
- LNP- encapsulated siRNA expressing an intracellular protein in vitro
- LNP-encapsulated siRNA expressing an intracellular protein in vivo
- LNP-encapsulated siRNA expressing an extracellular protein in vitro
- LNP-encapsulated siRNA expressing an extracellular protein in vivo
Figure 2: Model Parameters
Each model in Applied BioMath Assess™ Gene Therapy Model Pack has a unique set of parameters, a sample of which is shown here, based on the model pharmacology and number of compartments. More details on the full list of parameters are available upon request. In the app, each parameter contains a default value based on expansive literature searches and references.
Additional Model Packs
Biotherapeutic Model Pack: 18 models covering 9 common pharmacologies.
Cell Engager Model Pack: models for solid tumors, in-vitro experiments, and solid tumors with 2 cell types.
Avidity Model Pack: models covering both soluble and membrane ligand pharmacologies
Protein Degrader Model Pack: 4 models covering in vivo and in vitro models of PROTAC and Molecular Glue Degrader pharmacologies.