Quantitative Systems Pharmacology (QSP) Modeling for Immunotherapy-induced Cytokine Release Syndrome
Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease
Abstract
Background
Recent clinical trials of Aβ antibodies have established a causative relationship between plaque reduction and positive clinical and functional outcomes. Therefore, Applied Biomath undertook an exercise to quantitatively assess the antibody characteristics that predict Aβ plaque clearance by evaluating the effect of various classes of anti-Aβ therapeutic approaches to better predict potential clinical benefit.
Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions
Published in Frontiers in Pharmacology
Two heads are better than one: current landscape of integrating QSP and machine learning
Published in the Journal of Pharmacokinetics and Pharmacodynamics