Webinar Details
Recorded on Thursday, July 20, 2023
Speaker: Marc Presler, PhD, Senior Principal Scientist at Applied BioMath
Abstract:
- Regulatory agencies recommend quantitative justifications for clinical dose selection.
- T-cell engagers (TCE) pose particular challenges for dosing due to their multi-specific binding and avidity-based mechanism.
- We present an improved mathematical model where the target doses are sensitive to the cell-surface density of TCE targets, rather than receptor concentration.
- This model is robust to common discrepancies between experimental and clinical conditions, which often reduce accuracy of traditional models.